A CU research team has developed methods for detecting hybridization of nucleic acids using liquid crystals (LC) and cationic surfactant monolayers without the need for molecular labels and/or complex diagnostic equipment. While the system has not been optimized, University of Colorado researchers have demonstrated that the technology can differentiate a one base pair mismatch in a 16mer target at a sensitivity of 50 fmol. While this sensitivity cannot currently compete with that using standard fluorescence scanning, expensive equipment is not needed and thus would permit the adaptation for use in home, point-of-care, or field-based assays.
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