A CU research group has developed an improved method for designing barcodes for use in high throughput sequencing, e.g. pyrosequencing. These barcodes, uniquely, can both detect and correct sequencing errors, thus allowing high-confidence sequencing of hundreds of samples in a single pyrosequencing run.The technology has the potential to revolutionize several areas of research such as microbial community analysis, gene expression analysis, genomics, allele detection, diagnostic assays, and many other applications of high-throughput sequencing (especially as the read length improves and the number of sequences per plate increases). The improved barcodes will also make the technology far more accessible because many users can share a single run rather than paying for the full cost individually, thus allowing more labs to afford a taste of the technology for speculative but innovative research projects.
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