LPL) is a multifunctional enzyme produced by many tissues including adipose tissue and muscle, and is also present throughout the nervous system. A selective knockout of the LPL gene in the brain leads to development of severe obesity in mammals. This effect is mediated by the hippocampus. Since the hippocampus is involved in memory function, it is believed that LPL also plays a role in other diseases such as memory related diseases, for example, Alzheimer’s disease, age related senility, as well as other memory related diseases.
A research team from the University of Colorado led by Dr. Robert Eckel has developed a technique for modulating the activity of Lipoprotein lipase (LPL) in the brain, opening the door for new therapies to treat obesity and related memory disorders, and new methods of regulating body weight.
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