Monday, November 7, 2011

Podcast: Colorado Technology Infrastructure and BioFrontiers Institute

W3W3 radio interviewed Jim Linfield, Managing Partner at Cooley LLP and the recipient of TTO’s Colorado Technology Infrastructure Leadership Award in 2011. Speaking about CU’s newly-launched BioFrontiers Institute (an interdisciplinary center designed to advance transformational biotechnologies), Linfield said: "I think that will solidify CU's position as one of the leading institutions for interdisciplinary research in the life sciences area, covering both therapeutics and diagnostics but also bio fuels, so I think it will be a remarkable institution."

Listen to the podcast, or view an archive of all TTO podcasts.

Tuesday, November 1, 2011

Tech Spotlight: Enhancement of Radiotherapy and Prevention of Tumor Repopulation, Metastasis, and Recurrence

Radiotherapy and chemotherapy are the current standards of care for most cancers. While these treatment methods eradicate the tumor, they also initiate a process called “accelerated repopulation.” In this process, surviving tumor cells rapidly proliferate, repopulating the irradiated area at an accelerated pace. Further complicating cancer treatment, radiation and chemotherapy regimens incorporate necessary intervals in treatment, allowing for the recovery, survival, and repopulation of normal cellular tissue. Unfortunately, these breaks in treatment, paired with “accelerated repopulation,” allow for rapid growth of tumor cells. In fact, this issue of repopulation is a common cause of cancer treatment failure.

Dr. Chuan-Yuan Li, at the University of Colorado Cancer Center, has discovered a molecular signaling pathway integral in the process of “accelerated repopulation.” In a recent publication, Dr. Li has shown that apoptotic cells release growth signals that stimulate the proliferation of progenitor cells, and he has identified Caspase-3 as a key factor in this signaling event. With this scientific finding, Dr. Li has developed an approach to prevent tumor repopulation and metastasis, enhancing the effectiveness of cancer treatment.

To learn more, please view a short, non-confidential summary of Dr. Li's work, or go directly to the key scientific publication. For more CU technologies available for licensing, please visit our Tech Explorer site.